| First Author | Hoser D | Year | 2018 |
| Journal | Blood | Volume | 132 |
| Issue | 9 | Pages | 924-934 |
| PubMed ID | 30002144 | Mgi Jnum | J:266176 |
| Mgi Id | MGI:6201907 | Doi | 10.1182/blood-2018-02-834036 |
| Citation | Hoser D, et al. (2018) Oncogene-specific T cells fail to eradicate lymphoma-initiating B cells in mice. Blood 132(9):924-934 |
| abstractText | To date, little is known about the interaction between (pre-)malignant B cells and T cells. We generated transgenic mice that allow B cell-specific induction of the oncogene SV40 large T-antigen (TAg) to analyze the role of oncogene-specific T cells during sporadic B-cell lymphoma development. Constitutive TAg expression in CD19-Cre x LoxP-Tag mice resulted in TAg-tolerant CD8(+) T cells and development of B-cell lymphomas. In contrast, CD19-CreER(T2) x LoxP-Tag mice retained TAg-competent CD8(+) T cells at time of oncogene induction and TAg expression in few B cells of adult mice resulted in exceptionally rare lymphoma formation late in life. Increased lymphoma incidence in the absence of TAg-specific T cells suggested T cell-mediated inhibition of lymphoma progression. However, TAg-initiated B cells were not eliminated by T cells and detected long term. Our results demonstrate a failure of the immune system to eradicate lymphoma-initiating B cells, retaining the risk of lymphoma development. |
