| First Author | Chang SL | Year | 2009 |
| Journal | Mol Immunol | Volume | 46 |
| Issue | 16 | Pages | 3218-23 |
| PubMed ID | 19744714 | Mgi Jnum | J:155239 |
| Mgi Id | MGI:4413385 | Doi | 10.1016/j.molimm.2009.08.014 |
| Citation | Chang SL, et al. (2009) Role of Cybr, a cytohesin binder and regulator, in CD4(+) T-cell function and host immunity. Mol Immunol 46(16):3218-23 |
| abstractText | Cytohesin binder and regulator (Cybr) is known to regulate leukocyte adhesion and migration. However, its function in T-cells is poorly understood. Here, we investigated the role of Cybr in CD4(+) T-cell function and host immunity. Cybr inhibited p38 phosphorylation following CD4(+) T-cell stimulation. Since p38 regulates the expression of T-box expressed in T-cells (T-bet) but not GATA binding protein 3 (GATA-3) in T-cells, Cybr decreased the expression of T-bet and IFN-gamma in CD4(+) T-cells. Moreover, we found that host immunity against Listeria infection and IFN-gamma production in blood were significantly compromised in Cybr-overexpressing transgenic mice. In summary, our data suggest that Cybr represses the expression of T-bet and IFN-gamma via an inhibition of p38 in T-cells and consequently reduces host resistance to bacterial infection in mice. |
