| First Author | Zhang R | Year | 2021 |
| Journal | Front Cell Dev Biol | Volume | 9 |
| Pages | 687099 | PubMed ID | 34277628 |
| Mgi Jnum | J:322457 | Mgi Id | MGI:6729412 |
| Doi | 10.3389/fcell.2021.687099 | Citation | Zhang R, et al. (2021) Transforming Growth Factor-beta Signaling Regulates Tooth Root Dentinogenesis by Cooperation With Wnt Signaling. Front Cell Dev Biol 9:687099 |
| abstractText | Proper differentiation of odontoblasts is crucial for the development of tooth roots. Previous studies have reported the osteogenic/odontogenic potential of pre-odontoblasts during root odontoblast differentiation. However, the underlying molecular pathway that orchestrates these processes remains largely unclear. In this study, ablation of transforming growth factor-beta receptor type 2 (Tgfbr2) in root pre-odontoblasts resulted in abnormal formation of root osteodentin, which was associated with ectopic osteogenic differentiation of root odontoblasts. Disrupting TGF-beta signaling caused upregulation of Wnt signaling characterized by increased Wnt6, Wnt10a, Tcf-1, and Axin2 expression. Interestingly, inhibiting Wnt signaling by deleting Wntless (wls) in Osteocalcin (Ocn)-Cre; Tgfbr2 (fl/fl) ; Wls (fl/fl) mice or overexpressing the Wnt antagonist Dkk1 in Ocn-Cre; Tgfbr2 (fl/fl) ; ROSA26 (Dkk1) mice decreased ectopic osteogenic differentiation and arrested odontoblast differentiation. Our results suggest that TGF-beta signaling acts with Wnt signaling to regulate root odontogenic differentiation. |
