| Primary Identifier | MGI:1298382 | Organism | mouse, laboratory |
| Chromosome | X | NCBI Gene Number | 18824 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable chemokine binding activity. Predicted to be located in plasma membrane. Predicted to be active in membrane. Is expressed in central nervous system; cranium; sensory organ; and stomach. Orthologous to human PLP2 (proteolipid protein 2). PHENOTYPE: Males hemizygous for a null allele show increased neuronal apoptosis to ER stress and hypoxia in vitro and in a neonatal hypoxia-ischemia model in vivo. Mutant mouse embryonic fibroblasts show delayed ER trafficking, increased basal ER stress and increased sensitivity to ER stress-induced apoptosis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
