| First Author | Hartenstein B | Year | 2002 |
| Journal | EMBO J | Volume | 21 |
| Issue | 23 | Pages | 6321-9 |
| PubMed ID | 12456639 | Mgi Jnum | J:80663 |
| Mgi Id | MGI:2446755 | Doi | 10.1093/emboj/cdf648 |
| Citation | Hartenstein B, et al. (2002) Th2 cell-specific cytokine expression and allergen-induced airway inflammation depend on JunB. EMBO J 21(23):6321-9 |
| abstractText | Naive CD4+ T cells differentiate into effector T helper 1 (Th1) or Th2 cells, which are classified by their specific set of cytokines. Here we demonstrate that loss of JunB in in vitro polarized Th2 cells led to a dysregulated expression of the Th2-specific cytokines IL-4 and IL-5. These cells produce IFN-gamma and express T-bet, the key regulator of Th1 cells. In line with the essential role of Th2 cells in the pathogenesis of allergic asthma, mice with JunB-deficient CD4+ T cells exhibited an impaired allergen-induced airway inflammation. This study demonstrates novel functions of JunB in the development of Th2 effector cells, for a normal Th2 cytokine expression pattern and for a complete Th2-dependent immune response in mice. |
