| First Author | Avitahl N | Year | 1999 |
| Journal | Immunity | Volume | 10 |
| Issue | 3 | Pages | 333-43 |
| PubMed ID | 10204489 | Mgi Jnum | J:54058 |
| Mgi Id | MGI:1334056 | Doi | 10.1016/s1074-7613(00)80033-3 |
| Citation | Avitahl N, et al. (1999) Ikaros sets thresholds for T cell activation and regulates chromosome propagation. Immunity 10(3):333-43 |
| abstractText | T cell activation involves the sustained accumulation of T cell receptor (TCR) and IL-2 receptor (IL-2R) mediated signaling events that promote cell cycle entry and progression. The Ikaros family of nuclear factors regulate this process by providing thresholds overcome by receptor signaling. T cells with reduced levels of Ikaros activity require fewer TCR engagement events for activation, exhibit a greater proliferative response to IL-2, and are less sensitive to inhibitors of TCR and IL-2R signaling. Upon T cell activation, Ikaros proteins localize in a higher-order chromatin structure where they colocalize with components of the DNA replication machinery. Proliferating T cells with reduced Ikaros activity display chromosome abnormalities. We propose that participation of Ikaros in higher-order chromatin structures controls cell cycle transitions and restricts DNA replication. |
