| First Author | Mackay LK | Year | 2016 |
| Journal | Science | Volume | 352 |
| Issue | 6284 | Pages | 459-63 |
| PubMed ID | 27102484 | Mgi Jnum | J:232474 |
| Mgi Id | MGI:5779429 | Doi | 10.1126/science.aad2035 |
| Citation | Mackay LK, et al. (2016) Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes. Science 352(6284):459-63 |
| abstractText | Tissue-resident memory T (Trm) cells permanently localize to portals of pathogen entry, where they provide immediate protection against reinfection. To enforce tissue retention, Trm cells up-regulate CD69 and down-regulate molecules associated with tissue egress; however, a Trm-specific transcriptional regulator has not been identified. Here, we show that the transcription factor Hobit is specifically up-regulated in Trm cells and, together with related Blimp1, mediates the development of Trm cells in skin, gut, liver, and kidney in mice. The Hobit-Blimp1 transcriptional module is also required for other populations of tissue-resident lymphocytes, including natural killer T (NKT) cells and liver-resident NK cells, all of which share a common transcriptional program. Our results identify Hobit and Blimp1 as central regulators of this universal program that instructs tissue retention in diverse tissue-resident lymphocyte populations. |
