| First Author | Chen H | Year | 2021 |
| Journal | iScience | Volume | 24 |
| Issue | 11 | Pages | 103387 |
| PubMed ID | 34841225 | Mgi Jnum | J:324795 |
| Mgi Id | MGI:6832768 | Doi | 10.1016/j.isci.2021.103387 |
| Citation | Chen H, et al. (2021) The role of protease-activated receptor 1 signaling in CD8 T cell effector functions. iScience 24(11):103387 |
| abstractText | CD8 T cells are essential for adaptive immunity against viral infections. Protease activated receptor 1 (PAR1) is expressed by CD8 T cells; however, its role in T cell effector function is not well defined. Here we show that in human CD8 T cells, PAR1 stimulation accelerates calcium mobilization. Furthermore, PAR1 is involved in cytotoxic T cell function by facilitating granule trafficking via actin polymerization and repositioning of the microtubule organizing center (MTOC) toward the immunological synapse. In vivo, PAR1(-/-) mice have reduced cytokine-producing T cells in response to a lymphocytic choriomeningitis virus (LCMV) infection and fail to efficiently control the virus. Specific deletion of PAR1 in LCMV GP33-specific CD8 T cells results in reduced expansion and diminished effector function. These data demonstrate that PAR1 plays a role in T cell activation and function, and this pathway could represent a new therapeutic strategy to modulate CD8 T cell effector function. |
