| First Author | Kranz DM | Year | 1985 |
| Journal | Science | Volume | 227 |
| Issue | 4689 | Pages | 941-5 |
| PubMed ID | 3918347 | Mgi Jnum | J:7727 |
| Mgi Id | MGI:56196 | Doi | 10.1126/science.3918347 |
| Citation | Kranz DM, et al. (1985) Chromosomal locations of the murine T-cell receptor alpha-chain gene and the T-cell gamma gene. Science 227(4689):941-5 |
| abstractText | Two independent methods were used to identify the mouse chromosomes on which are located two families of immunoglobulin (Ig)-like genes that are rearranged and expressed in T lymphocytes. The genes coding for the alpha subunit of T-cell receptors are on chromosome 14 and the gamma genes, whose function is yet to be determined, are on chromosome 13. Since genes for the T-cell receptor beta chain were previously shown to be on mouse chromosome 6, all three of the Ig-like multigene families expressed and rearranged in T cells are located on different chromosomes, just as are the B-cell multigene families for the Ig heavy chain, and the Ig kappa and lambda light chains. The findings do not support earlier contentions that genes for T-cell receptors are linked to the Ig heavy chain locus (mouse chromosome 12) or to the major histocompatibility complex (mouse chromosome 17). |
