| First Author | Lundwall A | Year | 1997 |
| Journal | Eur J Biochem | Volume | 249 |
| Issue | 1 | Pages | 39-44 |
| PubMed ID | 9363751 | Mgi Jnum | J:71106 |
| Mgi Id | MGI:2149186 | Doi | 10.1111/j.1432-1033.1997.t01-2-00039.x |
| Citation | Lundwall A, et al. (1997) Chemical characterization of the predominant proteins secreted by mouse seminal vesicles. Eur J Biochem 249(1):39-44 |
| abstractText | Mouse seminal vesicles secrete four major protein components with estimated molecular masses of 95, 38, 17, and 16 kDa. Amino acid sequencing revealed that the 95-kDa component represents a protein with an unknown structure, while the 38-kDa component was identified as semenoclotin, the 17-kDa component as seminal-vesicle-secreted protein IV, and the 16-kDa component as seminal-vesicle-secreted protein V. Semenoclotin and the 95-kDa component were readily cross-linked by transglutaminase, suggesting that the two proteins are involved in the formation of the mouse copulatory plug. Treatment of mouse seminal vesicle fluid with human prostate-specific antigen rapidly degraded semenoclotin, indicating a structural resemblance of this protein to human semenogelins, despite the vast difference in primary structure. As previously reported for other seminal-vesicle-secreted proteins, the semenoclotin transcripts are shown to be under androgen control. |
