| Primary Identifier | MGI:1261758 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 52615 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.4.0) Enables nucleic acid binding activity and promoter-specific chromatin binding activity. Involved in facultative heterochromatin formation. Acts upstream of or within several processes, including negative regulation of macromolecule biosynthetic process; oligodendrocyte differentiation; and positive regulation of cell population proliferation. Located in nucleus and sex chromatin. Part of nucleus; protein-DNA complex; and ribonucleoprotein complex. Is expressed in several structures, including bone; branchial arch; central nervous system; limb bud; and sensory organ. Human ortholog(s) of this gene implicated in renal Wilms' tumor. Orthologous to human SUZ12 (SUZ12 polycomb repressive complex 2 subunit). PHENOTYPE: Homozygous null mice die during early postimplantation stages with failure of embryonic and extraembyronic tissues and organogenesis. Mice heterozygous for a knock-out allele exhibit abnormal brain and spinal cord development with varying penetrance. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
