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Allele : Lyve1<tm1.1(EGFP/cre)Cys> lymphatic vessel endothelial hyaluronan receptor 1; targeted mutation 1, Jason G Cyster
Primary Identifier  MGI:4421655 Allele Type  Targeted
Attribute String  Recombinase Gene  Lyve1
Transmission  Germline Strain of Origin  129P2/OlaHsd
Is Recombinase  true Is Wild Type  false
molecularNote  An EGFP fused to a humanized cre (hCre) sequence and preceded by an internal ribosomal entry site (IRES) was inserted into the 3' UTR of the Lyve1 locus by homologous recombination in E14 ES cells. This construct was followed by an FRT-flanked neo selection cassette. Three successfully targeted clones were injected into C57BL/6 blastocysts and chimeras derived from clone 9 were bred to get germline transmission. The neo cassette was deleted in the germline with Flp recombinase. Selective GFP expression in nuclei of Lyve1 +ve cells is detected by antibody staining.
  • mutations:
  • Insertion
  • synonyms:
  • Lyve-1 EGFP-hCre,
  • Lyve-1 EGFP-hCre,
  • Lyve-1 Cre<+>,
  • Lyve-1 Cre<+>
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0 Mutation Involves

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