| First Author | Hilpert C | Year | 2019 |
| Journal | J Immunol | Volume | 203 |
| Issue | 11 | Pages | 3068-3077 |
| PubMed ID | 31659017 | Mgi Jnum | J:282183 |
| Mgi Id | MGI:6379875 | Doi | 10.4049/jimmunol.1900320 |
| Citation | Hilpert C, et al. (2019) Dendritic Cells Control Regulatory T Cell Function Required for Maintenance of Intestinal Tissue Homeostasis. J Immunol 203(11):3068-3077 |
| abstractText | Dendritic cells (DCs) together with regulatory T cells (Tregs) are essential mediators of immune homeostasis. Disruption of function or frequency of either cell type can lead to fatal autoimmunity. We previously described that mice constitutively lacking DCs (DC) develop autoimmunity characterized by reduced body weight, autoantibodies, and pronounced intestinal inflammation. In this study, we show that lack of DCs leads to an altered gene expression profile in peripheral but not thymic Tregs with increased expression of inhibitory receptors. The suppressive function of Tregs from DeltaDC mice was impaired in T cell cocultures. In a model of transfer colitis, Tregs from DC mice were only functional in the presence of DCs in recipient mice. Lack of MHC class II on DCs also resulted in upregulation of inhibitory receptors on Tregs, reduced body weight, and elevated serum IgA levels. Further analysis of the IgA response revealed an expansion of IgA(+) germinal center B cells and plasma cells in mesenteric lymph nodes and more IgA-coated commensal bacteria in feces of DC mice. Thus, we show a critical role for DCs to establish intestinal homeostasis by regulating Treg function for prevention of spontaneous inflammation. |
