| First Author | Cooke JE | Year | 1996 |
| Journal | Dev Biol | Volume | 174 |
| Issue | 1 | Pages | 14-21 |
| PubMed ID | 8626013 | Mgi Jnum | J:31634 |
| Mgi Id | MGI:79120 | Doi | 10.1006/dbio.1996.0047 |
| Citation | Cooke JE, et al. (1996) The role of interleukin-4 in the regulation of mouse primordial germ cell numbers. Dev Biol 174(1):14-21 |
| abstractText | Interleukin-4 (IL-4), a pleiotropic cytokine, stimulates a dose-dependent increase in the number of mouse primordial germ cells in culture. Results from bromodeoxyuridine incorporation assays suggest that IL-4 acts as a survival factor rather than as a mitogen for primordial germ cells in this system. Studies on the embryonic expression patterns of IL-4 and its receptors, using RT-PCR and ELISA, show that IL-4 and its receptors are present at the correct time and place to influence PGC numbers in vivo. |
