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Publication : Involvement of mammalian Mus81 in genome integrity and tumor suppression.

First Author  McPherson JP Year  2004
Journal  Science Volume  304
Issue  5678 Pages  1822-6
PubMed ID  15205536 Mgi Jnum  J:91570
Mgi Id  MGI:3047477 Doi  10.1126/science.1094557
Citation  McPherson JP, et al. (2004) Involvement of mammalian Mus81 in genome integrity and tumor suppression. Science 304(5678):1822-6
abstractText  Mus81-Eme1 endonuclease has been implicated in the rescue of stalled replication forks and the resolution of meiotic recombination intermediates in yeast. We used gene targeting to study the physiological requirements of Mus81 in mammals. Mus81-/- mice are viable and fertile, which indicates that mammalian Mus81 is not essential for recombination processes associated with meiosis. Mus81-deficient mice and cells were hypersensitive to the DNA cross-linking agent mitomycin C but not to gamma-irradiation. Remarkably, both homozygous Mus81-/- and heterozygous Mus81+/- mice exhibited a similar susceptibility to spontaneous chromosomal damage and a profound and equivalent predisposition to lymphomas and other cancers. These studies demonstrate a critical role for the proper biallelic expression of the mammalian Mus81 in the maintenance of genomic integrity and tumor suppression.
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