| Primary Identifier | MGI:104724 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 14149 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable NADPH binding activity and NADPH-adrenodoxin reductase activity. Predicted to be involved in NADPH oxidation and steroid biosynthetic process. Predicted to act upstream of or within cholesterol metabolic process. Located in mitochondrial inner membrane. Orthologous to human FDXR (ferredoxin reductase). PHENOTYPE: Mice homozygous for a knock-out allele exhibit abnormal embryonic development and embryonic lethality likely due to iron overload. Heterozygotes exhibit premature death and are prone to spontaneous tumors and liver abnormalities, including steatosis, hepatitis, and hepatocellular carcinoma. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
