| First Author | Della Torre S | Year | 2016 |
| Journal | Cell Rep | Volume | 15 |
| Issue | 2 | Pages | 360-71 |
| PubMed ID | 27050513 | Mgi Jnum | J:234947 |
| Mgi Id | MGI:5792468 | Doi | 10.1016/j.celrep.2016.03.019 |
| Citation | Della Torre S, et al. (2016) An Essential Role for Liver ERalpha in Coupling Hepatic Metabolism to the Reproductive Cycle. Cell Rep 15(2):360-71 |
| abstractText | Lipoprotein synthesis is controlled by estrogens, but the exact mechanisms underpinning this regulation and the role of the hepatic estrogen receptor alpha (ERalpha) in cholesterol physiology are unclear. Utilizing a mouse model involving selective ablation of ERalpha in the liver, we demonstrate that hepatic ERalpha couples lipid metabolism to the reproductive cycle. We show that this receptor regulates the synthesis of cholesterol transport proteins, enzymes for lipoprotein remodeling, and receptors for cholesterol uptake. Additionally, ERalpha is indispensable during proestrus for the generation of high-density lipoproteins efficient in eliciting cholesterol efflux from macrophages. We propose that a specific interaction with liver X receptor alpha (LXRalpha) mediates the broad effects of ERalpha on the hepatic lipid metabolism. |
