Primary Identifier | MGI:1099790 | Organism | mouse, laboratory |
Chromosome | 13 | NCBI Gene Number | 20620 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Enables protein serine/threonine kinase activity. Involved in several processes, including negative regulation of apoptotic process in bone marrow cell; negative regulation of cellular senescence; and positive regulation of cell migration involved in sprouting angiogenesis. Acts upstream of or within mitotic cell cycle and negative regulation of apoptotic process. Part of chromatin. Is expressed in several structures, including alimentary system; hindlimb interdigital region; integumental system; nervous system; and skeleton. Orthologous to human PLK2 (polo like kinase 2). PHENOTYPE: Inactivation of this gene results in impaired embryonic growth and placental defects due to increased cell proliferation. [provided by MGI curators] |