| Primary Identifier | MGI:1918055 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 226976 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to be involved in positive regulation of transcription by RNA polymerase II and regulation of mitochondrial transcription. Part of NSL complex. Is expressed in 1-cell stage embryo; 2-cell stage embryo; 8-cell stage embryo; blastocyst; and brain. Orthologous to human KANSL3 (KAT8 regulatory NSL complex subunit 3). PHENOTYPE: Mice homozygous for a knock-out allele fail to hatch out of the zona pelucida both in vivo and in vitro, and show implantation failure and lineage-specific defects at the blastocyst stage with significantly reduced inner cell mass, epiblast, and primitive endoderm cell numbers, leading to peri-implantation lethality. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
