| Primary Identifier | MGI:6164037 | Allele Type | Transgenic |
| Attribute String | Constitutively active, Inserted expressed sequence | Gene | Tg(Vav1-STAT5B*N642H)726Biat |
| Strain of Origin | C57BL/6NCrl | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | The human STAT5B harboring the N642H mutation in the SH2 domain is under the control of the hematopoietic specific Vav1 promoter. This is a gain-of-function mutation in leukemic patients that causes enhanced and prolonged tyrosine phosphorylation. |
