| First Author | McCarrey JR | Year | 1992 |
| Journal | Nat Genet | Volume | 2 |
| Issue | 3 | Pages | 200-3 |
| PubMed ID | 1345169 | Mgi Jnum | J:3164 |
| Mgi Id | MGI:51679 | Doi | 10.1038/ng1192-200 |
| Citation | McCarrey JR, et al. (1992) Expression of Xist in mouse germ cells correlates with X-chromosome inactivation. Nat Genet 2(3):200-3 |
| abstractText | Mammals compensate for different doses of X-chromosome-linked genes in male (XY) and female (XX) somatic cells by terminally inactivating all but one X chromosome in each cell. A transiently inactive X chromosome is also found in germ cells, specifically in premeiotic oogenic cells and in meiotic and postmeiotic spermatogenic cells. Here we show that the Xist gene, which is a expressed predominantly from the inactive X-chromosome in female somatic cells, is also expressed in germ cells of both sexes, but only at those stages when an inactive X chromosome is present. This suggests support for the putative role of Xist as a regulator of X-chromosome inactivation and suggest a common mechanism for the initiation and/or maintenance of X-chromosome inactivation in all cell types. |
