First Author | Maity SN | Year | 1998 |
Journal | Trends Biochem Sci | Volume | 23 |
Issue | 5 | Pages | 174-8 |
PubMed ID | 9612081 | Mgi Jnum | J:47785 |
Mgi Id | MGI:1206025 | Doi | 10.1016/s0968-0004(98)01201-8 |
Citation | Maity SN, et al. (1998) Role of the CCAAT-binding protein CBF/NF-Y in transcription. Trends Biochem Sci 23(5):174-8 |
abstractText | The CCAAT motif is one of the common promoter elements present in the proximal promoter of numerous mammalian genes transcribed by RNA polymerase II. CBF (also called NF-Y and CP1) consists of three different subunits and interacts specifically with the CCAAT motif. In each CBF subunit, the segment needed for formation of the CBF-DNA complex is conserved from yeast to human and, interestingly, the conserved segment of two CBF subunits, CBF-A and CBF-C, are homologous to the histone-fold motif of eukaryotic histones and archaebacterial histone-like protein HMf-2. The histone fold motifs of CBF-A and CBF-C interact with each other to form a heterodimer that associates with CBF-B to form a heterotrimeric CBF molecule, which then binds to DNA. |