| First Author | Parent AT | Year | 2005 |
| Journal | J Neurosci | Volume | 25 |
| Issue | 6 | Pages | 1540-9 |
| PubMed ID | 15703408 | Mgi Jnum | J:98238 |
| Mgi Id | MGI:3577684 | Doi | 10.1523/JNEUROSCI.3850-04.2005 |
| Citation | Parent AT, et al. (2005) Presenilin attenuates receptor-mediated signaling and synaptic function. J Neurosci 25(6):1540-9 |
| abstractText | Presenilin (PS) plays an essential role in intramembranous gamma-secretase processing of amyloid precursor protein (APP) and several membrane-bound proteins. Here we report that selective accumulation of a membrane-tethered deleted in colorectal cancer (DCC) derivative (DCC-alpha) correlates with extensive neurite outgrowth in transfected neuroblastoma cells and axodendritic connectivity associated with increased spine density in cortical neurons derived from PS1(-/-) embryos, as well as wild-type neurons treated with gamma-secretase inhibitors. cAMP-dependent signaling was also increased in both the neuroblastoma and cortical neuron systems. As a physiological consequence of increases in axodendritic connectivity and in the magnitude of cAMP-dependent signaling, short- and long-term glutamatergic synaptic transmission was enhanced in PS-deficient neurons. Together, these results demonstrate for the first time that PS-mediated gamma-secretase activity attenuates receptor-mediated intracellular signaling pathways that are critical in regulating glutamatergic synaptic transmission and memory processes. |
