| First Author | Jacobshagen M | Year | 2014 |
| Journal | Development | Volume | 141 |
| Issue | 17 | Pages | 3370-7 |
| PubMed ID | 25078650 | Mgi Jnum | J:215912 |
| Mgi Id | MGI:5607347 | Doi | 10.1242/dev.108043 |
| Citation | Jacobshagen M, et al. (2014) The serotonin 6 receptor controls neuronal migration during corticogenesis via a ligand-independent Cdk5-dependent mechanism. Development 141(17):3370-7 |
| abstractText | The formation of a laminar structure such as the mammalian neocortex relies on the coordinated migration of different subtypes of excitatory pyramidal neurons in specific layers. Cyclin-dependent kinase 5 (Cdk5) is a master regulator of pyramidal neuron migration. Recently, we have shown that Cdk5 binds to the serotonin 6 receptor (5-HT6R), a G protein-coupled receptor (GPCR). Here, we investigated the role of 5-HT6R in the positioning and migration of pyramidal neurons during mouse corticogenesis. We report that constitutive expression of 5-HT6R controls pyramidal neuron migration through an agonist-independent mechanism that requires Cdk5 activity. These data provide the first in vivo evidence of a role for constitutive activity at a GPCR in neocortical radial migration. |
