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Protein Coding Gene : Polr3a polymerase (RNA) III (DNA directed) polypeptide A

Primary Identifier  MGI:2681836 Organism  mouse, laboratory
Chromosome  14 NCBI Gene Number  218832
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.4.0)

Enables chromatin binding activity. Predicted to be involved in innate immune response; positive regulation of interferon-beta production; and tRNA transcription by RNA polymerase III. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of RNA polymerase III complex. Human ortholog(s) of this gene implicated in Wiedemann-Rautenstrauch syndrome and hypomyelinating leukodystrophy 7. Orthologous to human POLR3A (RNA polymerase III subunit A).
PHENOTYPE: Mice homozygous for a knock-out allele are embryonically lethal. Surprisingly, mice homozygous for the G672E hypomyelinating leukodystrophy mutation show no evidence of hypomyelination, cerebellar atrophy, Purkinje cell loss or significant motor dysfunction. [provided by MGI curators]
  • synonyms:
  • 9330175N20Rik,
  • Polr3a,
  • RPC155,
  • cDNA sequence BC053071,
  • RIKEN cDNA 9330175N20 gene,
  • MGI:1924764,
  • BC053071,
  • RPC1,
  • polymerase (RNA) III (DNA directed) polypeptide A,
  • MGC:62420

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Genome

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0 Exons

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0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

6 Pathways

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Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

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