Primary Identifier | MGI:1891832 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 56218 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and chromatin binding activity. Involved in negative regulation of endothelial cell migration. Acts upstream of or within several processes, including T cell differentiation; male gonad development; and positive regulation of DNA-templated transcription. Located in male germ cell nucleus. Is expressed in several structures, including alimentary system; genitourinary system; limb bud; nervous system; and sensory organ. Orthologous to human PATZ1 (POZ/BTB and AT hook containing zinc finger 1). PHENOTYPE: Mice homozygous for a null allele exhibit some embryonic and fetal lethality, exencephaly, nervous system defects, outflow defects, transposition of great arteries, postnatal growth retardation and male and female infertility. [provided by MGI curators] |