| First Author | Ndlovu H | Year | 2019 |
| Journal | J Leukoc Biol | Volume | 105 |
| Issue | 2 | Pages | 307-316 |
| PubMed ID | 30500088 | Mgi Jnum | J:270350 |
| Mgi Id | MGI:6276089 | Doi | 10.1002/JLB.MA0318-115R |
| Citation | Ndlovu H, et al. (2019) IL-4Ralpha-expressing CD11c(+) cells contribute to driving optimal cellular responses during Schistosoma mansoni infection in mice. J Leukoc Biol 105(2):307-316 |
| abstractText | Development of IL-4 receptor alpha (IL-4Ralpha)-dependent cellular immunity regulates host protection against acute schistosomiasis. In this study, we investigated the importance of IL-4Ralpha-expressing CD11c(+) cells in driving the development of optimal cellular responses to Schistosoma mansoni infection by using CD11c(cre) IL-4Ralpha(-/lox) BALB/c mice, which lacked IL-4Ralpha expression on dendritic cells and alveolar macrophages. Abrogation of IL-4Ralpha expression on CD11c(+) cells affected activation of CD4(+) T cells, resulting in reduced numbers of effector CD4(+) T cells and impaired production of Th1 and Th2 cytokines by CD4(+) T cells ex vivo. However, secretion of both type 1 and type 2 Ab isotypes was unchanged in infected CD11c-specific IL-4Ralpha-deficient mice compared to littermate controls. Together, these data demonstrate that IL-4Ralpha-expressing CD11c(+) cells play an important role in maintaining cellular immunity during schistosomiasis in mice. |
