| First Author | Soupene E | Year | 2006 |
| Journal | Br J Haematol | Volume | 133 |
| Issue | 4 | Pages | 436-8 |
| PubMed ID | 16643453 | Mgi Jnum | J:108558 |
| Mgi Id | MGI:3624236 | Doi | 10.1111/j.1365-2141.2006.06051.x |
| Citation | Soupene E, et al. (2006) Identification of an erythroid ATP-dependent aminophospholipid transporter. Br J Haematol 133(4):436-8 |
| abstractText | The asymmetric distribution of amino-containing phospholipids in plasma membranes is essential for the function and survival of mammalian cells. Phosphatidylserine (PS) is restricted to the inner leaflet of plasma membranes by an ATP-dependent transport process. Exposure of PS on the surface of cells serves as a binding site for haemostatic factors, triggers cell-cell interaction and recognition by macrophages and phospholipases. Exposure of PS on the red cell surface plays a significant role in sickle cell pathology. We report the identification of two different isoforms of the aminophospholipid translocase, Atp8a1, or flippase, in the murine red blood cell membrane. |
