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Publication : A secreted protein promotes cleavage furrow maturation during cytokinesis.

First Author  Xu X Year  2011
Journal  Curr Biol Volume  21
Issue  2 Pages  114-9
PubMed ID  21215633 Mgi Jnum  J:305110
Mgi Id  MGI:6693992 Doi  10.1016/j.cub.2010.12.006
Citation  Xu X, et al. (2011) A secreted protein promotes cleavage furrow maturation during cytokinesis. Curr Biol 21(2):114-9
abstractText  Developmental modifications in cell shape depend on dynamic interactions between the extracellular matrix and cytoskeleton. In contrast, existing models of cytokinesis describe substantial cell surface remodeling that involves many intracellular regulatory and structural proteins but includes no contribution from the extracellular matrix [1-3]. Here, we show that extracellular hemicentins assemble at the cleavage furrow of dividing cells in the C. elegans germline and in preimplantation mouse embryos. In the absence of hemicentin, cleavage furrows form but retract prior to completion, resulting in multinucleate cells. In addition to their role in tissue organization, the data indicate that hemicentins are the first secreted proteins required during mammalian development and the only known secreted proteins required for cytokinesis, with an evolutionarily conserved role in stabilizing and preventing retraction of nascent cleavage furrows. Together with studies showing that extracellular polysaccharides are required for cytokinesis in diverse species [4-9], our data suggest that assembly of a cell type-specific extracellular matrix may be a general requirement for cleavage furrow maturation and contractile ring function during cytokinesis.
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