| First Author | Mayer JU | Year | 2021 |
| Journal | Nat Immunol | Volume | 22 |
| Issue | 12 | Pages | 1538-1550 |
| PubMed ID | 34795444 | Mgi Jnum | J:321392 |
| Mgi Id | MGI:6874445 | Doi | 10.1038/s41590-021-01067-0 |
| Citation | Mayer JU, et al. (2021) Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote TH2 and inhibit TH17 cell polarization. Nat Immunol 22(12):1538-1550 |
| abstractText | The signals driving the adaptation of type 2 dendritic cells (DC2s) to diverse peripheral environments remain mostly undefined. We show that differentiation of CD11b(lo) migratory DC2s-a DC2 population unique to the dermis-required IL-13 signaling dependent on the transcription factors STAT6 and KLF4, whereas DC2s in lung and small intestine were STAT6-independent. Similarly, human DC2s in skin expressed an IL-4 and IL-13 gene signature that was not found in blood, spleen and lung DCs. In mice, IL-13 was secreted homeostatically by dermal innate lymphoid cells and was independent of microbiota, TSLP or IL-33. In the absence of IL-13 signaling, dermal DC2s were stable in number but remained CD11b(hi) and showed defective activation in response to allergens, with diminished ability to support the development of IL-4(+)GATA3(+) helper T cells (TH), whereas antifungal IL-17(+)RORgammat(+) TH cells were increased. Therefore, homeostatic IL-13 fosters a noninflammatory skin environment that supports allergic sensitization. |
