| First Author | Patarca R | Year | 1988 |
| Journal | Proc Natl Acad Sci U S A | Volume | 85 |
| Issue | 8 | Pages | 2733-7 |
| PubMed ID | 2965815 | Mgi Jnum | J:9134 |
| Mgi Id | MGI:57597 | Doi | 10.1073/pnas.85.8.2733 |
| Citation | Patarca R, et al. (1988) rpt-1, an intracellular protein from helper/inducer T cells that regulates gene expression of interleukin 2 receptor and human immunodeficiency virus type 1 [published erratum appears in Proc Natl Acad Sci U S A 1988 Jul;85(14):5224. Proc Natl Acad Sci U S A 85(8):2733-7 |
| abstractText | The Rpt-1 (for regulatory protein, T-lymphocyte, 1) gene, selectively expressed by resting but not by activated CD4+ inducer T cells, encodes an intracellular protein (rpt-1, Mr 41,000) that down-regulates gene expression directed by the promoter region of the gene encoding interleukin 2 receptor alpha chain and by the long terminal repeat of human immunodeficiency virus type 1. The data reported here suggest that rpt-1 levels may be inversely correlated with activation of CD4+ T cells and human immunodeficiency virus replication leading to clinical symptoms of the acquired immunodeficiency syndrome. |
