| First Author | Oslowski CM | Year | 2012 |
| Journal | Cell Metab | Volume | 16 |
| Issue | 2 | Pages | 265-73 |
| PubMed ID | 22883234 | Mgi Jnum | J:187376 |
| Mgi Id | MGI:5436335 | Doi | 10.1016/j.cmet.2012.07.005 |
| Citation | Oslowski CM, et al. (2012) Thioredoxin-Interacting Protein Mediates ER Stress-Induced beta Cell Death through Initiation of the Inflammasome. Cell Metab 16(2):265-73 |
| abstractText | Recent clinical and experimental evidence suggests that endoplasmic reticulum (ER) stress contributes to the life-and-death decisions of beta cells during the progression of type 1 and type 2 diabetes. Although crosstalk between inflammation and ER stress has been suggested to play a significant role in beta cell dysfunction and death, a key molecule connecting ER stress to inflammation has not been identified. Here we report that thioredoxin-interacting protein (TXNIP) is a critical signaling node that links ER stress and inflammation. TXNIP is induced by ER stress through the PERK and IRE1 pathways, induces IL-1beta mRNA transcription, activates IL-1beta production by the NLRP3 inflammasome, and mediates ER stress-mediated beta cell death. Collectively, our results suggest that TXNIP is a potential therapeutic target for diabetes and ER stress-related human diseases such as Wolfram syndrome. |
