Primary Identifier | IPR012918 | Type | Family |
Short Name | RTP801-like |
description | RTP801, also known as REDD1, is the protein product of a hypoxia-inducible factor 1 (HIF-1)- responsive gene and is thought to be involved in various cellular processes []. Both RTP801 and RTP801-like (REDD2) work downstream of AKT and upstream of TSC2 to inhibit mTOR, a serine/threonine kinase that plays an essential role in cell growth control []. Two members of this family expressed by Drosophila melanogaster, Scylla () and Charybde (), are designated as Hox targets [, ]. |