Primary Identifier | MGI:108042 | Organism | mouse, laboratory |
Chromosome | 3 | NCBI Gene Number | 12427 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in mitotic cell cycle phase transition. Predicted to act upstream of or within several processes, including cell division; meiotic cell cycle; and spermatogenesis. Part of cyclin A1-CDK2 complex. Is expressed in several structures, including blastocyst; submandibular gland; telencephalon; testis; and tooth. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human CCNA1 (cyclin A1). PHENOTYPE: Homozygous null males are infertile due to the arrest of spermatogenesis prior to the first meiotic division. Female mutant mice are fertile. [provided by MGI curators] |