| First Author | Sun B | Year | 2020 |
| Journal | J Immunol | Volume | 205 |
| Issue | 12 | Pages | 3408-3418 |
| PubMed ID | 33177158 | Mgi Jnum | J:300739 |
| Mgi Id | MGI:6502553 | Doi | 10.4049/jimmunol.1901455 |
| Citation | Sun B, et al. (2020) NSUN5 Facilitates Viral RNA Recognition by RIG-I Receptor. J Immunol 205(12):3408-3418 |
| abstractText | The RIG-I receptor induces the innate antiviral responses upon sensing RNA viruses. The mechanisms through which RIG-I optimizes the strength of the downstream signaling remain incompletely understood. In this study, we identified that NSUN5 could potentiate the RIG-I innate signaling pathway. Deficiency of NSUN5 enhanced RNA virus proliferation and inhibited the induction of the downstream antiviral genes. Consistently, NSUN5-deficient mice were more susceptible to RNA virus infection than their wild-type littermates. Mechanistically, NSUN5 bound directly to both viral RNA and RIG-I, synergizing the recognition of dsRNA by RIG-I. Collectively, to our knowledge, this study characterized NSUN5 as a novel RIG-I coreceptor, playing a vital role in restricting RNA virus infection. |
