|  Help  |  About  |  Contact Us

Publication : Role of beta-catenin in synaptic vesicle localization and presynaptic assembly.

First Author  Bamji SX Year  2003
Journal  Neuron Volume  40
Issue  4 Pages  719-31
PubMed ID  14622577 Mgi Jnum  J:86623
Mgi Id  MGI:2680876 Doi  10.1016/s0896-6273(03)00718-9
Citation  Bamji SX, et al. (2003) Role of beta-catenin in synaptic vesicle localization and presynaptic assembly. Neuron 40(4):719-31
abstractText  Cadherins and catenins are thought to promote adhesion between pre and postsynaptic elements in the brain. Here we show a role for beta-catenin in localizing the reserved pool of vesicles at presynaptic sites. Deletion of beta-catenin in hippocampal pyramidal neurons in vivo resulted in a reduction in the number of reserved pool vesicles per synapse and an impaired response to prolonged repetitive stimulation. This corresponded to a dispersion of vesicles along the axon in cultured neurons. Interestingly, these effects are not due to beta-catenin's involvement in cadherin-mediated adhesion or wnt signaling. Instead, beta-catenin modulates vesicle localization via its PDZ binding domain to recruit PDZ proteins such as Veli to cadherin at synapses. This study defines a specific role for cadherins and catenins in synapse organization beyond their roles in mediating cell adhesion.
Quick Links:
 
Quick Links:
 

Expression

Publication --> Expression annotations

 

Other

18 Bio Entities

Trail: Publication

0 Expression