| First Author | DeNardo DG | Year | 2008 |
| Journal | Cancer Cell | Volume | 14 |
| Issue | 1 | Pages | 7-9 |
| PubMed ID | 18598939 | Mgi Jnum | J:138702 |
| Mgi Id | MGI:3806178 | Doi | 10.1016/j.ccr.2008.06.010 |
| Citation | DeNardo DG, et al. (2008) Inflaming gastrointestinal oncogenic programming. Cancer Cell 14(1):7-9 |
| abstractText | The etiology of gastrointestinal tumors implicates a role for chronic inflammation in response to pathogenic microflora as a promoting force for full neoplastic progression. Recently, Oguma and coworkers (2008) demonstrated that TNFalpha, derived from recruited macrophages, potentiates Wnt/beta-catenin signaling and gastric carcinogenesis by activating Akt signaling and GSK3beta phosphorylation independent of the NF-kappaB pathway in initiated epithelial cells. These observations provide a missing link in the mechanism whereby chronic inflammation, in response to Helicobacter, regulates the 'penetrance' of initiating oncogenic mutations in the gastrointestinal tract leading to gastrointestinal tumorigenesis. |
