| First Author | Whitmore AC | Year | 2004 |
| Journal | J Immunol | Volume | 173 |
| Issue | 9 | Pages | 5406-14 |
| PubMed ID | 15494487 | Mgi Jnum | J:93769 |
| Mgi Id | MGI:3505665 | Doi | 10.4049/jimmunol.173.9.5406 |
| Citation | Whitmore AC, et al. (2004) Rapid induction of splenic and peritoneal B-1a cells in adult mice by thymus-independent type-2 antigen. J Immunol 173(9):5406-14 |
| abstractText | We have produced a transgenic mouse (PV1TgL) that can only generate B lymphocytes with an Ig receptor specific for the synthetic polymer polyvinyl pyrrolidinone. Before immunization, bone marrow B cell numbers are very low, and peripheral lymphoid organs are almost devoid of B cells, confirming the role of positive selection by Ag in the development of mature B cell populations. The predominant population of B cells in the spleens of naive adult PV1TgL mice have most of the characteristics of marginal zone B cells, including anatomical location in the peripheral areas of the splenic white pulp. After immunization, a new population of B cells appears in the spleen with the characteristics of B-1 cells. Similar cells also appear somewhat later in the peritoneal cavity. Our findings suggest that immunization with a thymus-independent Ag can lead to the appearance and expansion of Ag-reactive B-1 cells in an adult mouse. |
