| First Author | Peckl-Schmid D | Year | 2010 |
| Journal | Eur J Immunol | Volume | 40 |
| Issue | 11 | Pages | 3161-72 |
| PubMed ID | 20865787 | Mgi Jnum | J:174159 |
| Mgi Id | MGI:5052007 | Doi | 10.1002/eji.200940221 |
| Citation | Peckl-Schmid D, et al. (2010) HAX1 deficiency: impact on lymphopoiesis and B-cell development. Eur J Immunol 40(11):3161-72 |
| abstractText | HAX1 was originally described as HS1-associated protein with a suggested function in receptor-mediated apoptotic and proliferative responses of lymphoid cells. Recent publications refer to a complex and multifunctional role of this protein. To investigate the in vivo function of HAX1 (HS1-associated protein X1) in B cells, we generated a Hax1-deficient mouse strain. Targeted deletion of Hax1 resulted in premature death around the age of 12 wk accompanied by a severe reduction of lymphocytes in spleen, thymus and bone marrow. In the bone marrow, all B-cell populations were lost comparably. In the spleen, B220(+) cells were reduced by almost 70%. However, as investigated by adoptive transfer experiments, this impairment is not exclusively B-cell intrinsic and we hypothesize that a HAX1-deficient environment cannot sufficiently provide the essential factors for proper lymphocyte development, trafficking and survival. Hax1(-/-) B cells show a significantly reduced expression of CXCR4, which might have an influence on the observed defects in B-cell development. |
