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Publication : <i>Plasmodium</i>-specific atypical memory B cells are short-lived activated B cells.

First Author  Pérez-Mazliah D Year  2018
Journal  Elife Volume  7
PubMed ID  30387712 Mgi Jnum  J:286195
Mgi Id  MGI:6402359 Doi  10.7554/eLife.39800
Citation  Pérez-Mazliah D, et al. (2018) Plasmodium-specific atypical memory B cells are short-lived activated B cells. Elife Nov 2(7):e39800
abstractText  A subset of atypical memory B cells accumulates in malaria and several infections, autoimmune disorders and aging in both humans and mice. It has been suggested these cells are exhausted long-lived memory B cells, and their accumulation may contribute to poor acquisition of long-lasting immunity to certain chronic infections, such as malaria and HIV. Here, we generated an immunoglobulin heavy chain knock-in mouse with a BCR that recognizes MSP1 of the rodent malaria parasite, Plasmodium chabaudi. In combination with a mosquito-initiated P. chabaudi infection, we show that Plasmodium-specific atypical memory B cells are short-lived and disappear upon natural resolution of chronic infection. These cells show features of activation, proliferation, DNA replication, and plasmablasts. Our data demonstrate that Plasmodium-specific atypical memory B cells are not a subset of long-lived memory B cells, but rather short-lived activated cells, and part of a physiologic ongoing B-cell response.
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