| Type | MGI:General | Description | ultrastructurally, many granular cells display intracellular edema formation and are lysed the number of cytokeratin filament bundles is significantly reduced cytokeratin aggregates are markedly smaller in homozygous than in heterozygous mutants and show a tendency to round up some of the remaining cytokeratin bundles display short wire-like filaments, while others are inconspicuous and tend to be associated with desmosomes or close to the plasma membrane the continuity of cytosplasmic intermediate filaments is severely disrupted the transition zone between granular and cornified layers is significantly broader than normal |
