| First Author | Day CE | Year | 1982 |
| Journal | Somatic Cell Genet | Volume | 8 |
| Issue | 6 | Pages | 691-707 |
| PubMed ID | 6819642 | Mgi Jnum | J:6998 |
| Mgi Id | MGI:55469 | Doi | 10.1007/BF01543012 |
| Citation | Day CE, et al. (1982) Mapping of the genes of some components of the electron transport chain (complex I) on the X chromosome of mammals. Somatic Cell Genet 8(6):691-707 |
| abstractText | This paper describes genetic mapping studies with several respiration-deficient mutants of Chinese hamster fibroblasts which have a defect in complex I of the electron transport chain (NADH-coenzyme Q reductase). The mutations associated with two different complementation groups map on the X chromosome. In two cases (G14 and G20) karyotypic and isozyme analyses in hybrids have shown that a gene(s) on the mouse X chromosome complements the mutation(s) in the hamster cell mutant(s). A cosegregation analysis in hybrid cells has shown the corresponding genes to be linked to the HPRT genes (hamster-mouse hybrids of G14, and hamster-hamster hybrids for G14 and G20). By the same method the defective gene in a third mutant (G4) was also shown to be X-linked. A mutation representing a third complementation group (G11) was shown to be on an autosomal gene. These results provide an explanation for our observation that cells with recessive mutations in complementation groups I and II can be selected at relatively high frequencies. |
