Primary Identifier | MGI:3764813 | Allele Type | Transgenic |
Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(CAG-SNCA*)1.1Ccs |
Strain of Origin | C57BL/6 | Is Recombinase | false |
Is Wild Type | false |
description | Four lines were created (1.10, 1.1, 1.5 and 1,9) with similar expression patterns and line 1.1 choosen as the representative line. |
molecularNote | This transgene contains a double mutant human SNCA with amino acid substitutions of proline for alanine at position 30 (A30P) and threonine for alanine at position 53 (A53T) under the control of a CMV enchanced, chicken beta-actin promoter. Expression is detected in the brain, kidney, lung, liver and heart. |