Primary Identifier | MGI:2178831 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Arnt2 |
Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
Is Recombinase | false | Is Wild Type | false |
molecularNote | An in-frame NLS-LacZ cassette was introduced into this gene via homologous recombination, disrupting the HLH domain which is involved in dimerization and DNA binding. Successful homologous recombination was confirmed by Southern blotting. Protein was not present in brain of neonate homozygous mutant animals via immunohistochemistry analysis. |