| First Author | Billet O | Year | 1995 |
| Journal | J Virol | Volume | 69 |
| Issue | 9 | Pages | 5912-6 |
| PubMed ID | 7637040 | Mgi Jnum | J:130457 |
| Mgi Id | MGI:3771696 | Doi | 10.1128/jvi.69.9.5912-5916.1995 |
| Citation | Billet O, et al. (1995) In vivo activity of the hepatitis B virus core promoter: tissue specificity and temporal regulation. J Virol 69(9):5912-6 |
| abstractText | The contribution of the hepatitis B virus enhancers I and II in the regulation of the activity of the core and the X promoters was assessed in transgenic mice. Surprisingly, despite the presence of heterologous promoters linked 5' of the X gene, the transgene expression is mostly due to core promoter (Cp) activity present in the X coding sequence. Moreover, the restriction of Cp activity to hepatic tissue required the combined action of both enhancers I and II, whereas the proximity of these two enhancers was insufficient to confer tissue specificity on Xp activity. Furthermore, the liver-specific activity of the Cp was developmentally regulated in an enhancer I-independent manner. |
