| First Author | Wan Y | Year | 2014 |
| Journal | FEBS Lett | Volume | 588 |
| Issue | 17 | Pages | 2928-35 |
| PubMed ID | 24911202 | Mgi Jnum | J:213486 |
| Mgi Id | MGI:5585193 | Doi | 10.1016/j.febslet.2014.05.043 |
| Citation | Wan Y, et al. (2014) Separation of zinc-dependent and zinc-independent events during early LPS-stimulated TLR4 signaling in macrophage cells. FEBS Lett 588(17):2928-35 |
| abstractText | Free zinc is required for proper lipopolysaccharide (LPS)-stimulated signaling, but potential sites of action in the pathway have not been defined. In this work, we provide in vitro and ex vivo evidence that zinc is not required for phosphorylation or ubiquitylation of IRAK1, a kinase functioning early in the TLR4 pathway. However, degradation of ubiquitylated IRAK1 occurred via a zinc-dependent, proteasome-independent pathway. These results provide evidence of a novel site of action for zinc during TLR4-mediated inflammatory responses. |
