| First Author | Angela M | Year | 2016 |
| Journal | Nat Commun | Volume | 7 |
| Pages | 13683 | PubMed ID | 27901044 |
| Mgi Jnum | J:243167 | Mgi Id | MGI:5907797 |
| Doi | 10.1038/ncomms13683 | Citation | Angela M, et al. (2016) Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARgamma directs early activation of T cells. Nat Commun 7:13683 |
| abstractText | To fulfil the bioenergetic requirements for increased cell size and clonal expansion, activated T cells reprogramme their metabolic signatures from energetically quiescent to activated. However, the molecular mechanisms and essential components controlling metabolic reprogramming in T cells are not well understood. Here, we show that the mTORC1-PPARgamma pathway is crucial for the fatty acid uptake programme in activated CD4+ T cells. This pathway is required for full activation and rapid proliferation of naive and memory CD4+ T cells. PPARgamma directly binds and induces genes associated with fatty acid uptake in CD4+ T cells in both mice and humans. The PPARgamma-dependent fatty acid uptake programme is critical for metabolic reprogramming. Thus, we provide important mechanistic insights into the metabolic reprogramming mechanisms that govern the expression of key enzymes, fatty acid metabolism and the acquisition of an activated phenotype during CD4+ T cell activation. |
