| Primary Identifier | IPR031077 | Type | Family |
| Short Name | HMGB3 |
| description | This entry represents HMGB3. It regulates the balance between hematopoietic stem cell self-renewal and differentiation []. It also inhibits myeloid and B-cell differentiation []. Overexpression of HMGB3 promotes cell proliferation, migration and is associated with poor prognosis of cancers [, ].The high mobility group (HMG) proteins are the most abundant and ubiquitous nonhistone chromosomal proteins. They bind to DNA and to nucleosomes and are involved in the regulation of DNA-dependent processes such as transcription, replication, recombination, and DNA repair. They can be grouped into three families: HMGB (HMG 1/2), HMGN (HMG 14/17) and HMGA (HMG I/Y). The characteristic domains are: AT-hook for the HMGA family, the HMG Box for the HMGB family, and the nucleosome-binding domain (NBD) for the members of the HMGN family []. |
