| Primary Identifier | IPR030181 | Type | Family |
| Short Name | BPI |
| description | Bactericidal/permeability-increasing protein (BPI) is a potent antimicrobial protein that binds to and neutralises lipopolysaccharide (LPS), a glycolipid present in the outer membrane of Gram-negative bacteria [].In mammals, two related LPS-binding proteins mediate the biological effects of LPS: LPS-binding protein (LBP) and BPI. LBP is a plasma protein that enhances the inflammatory response to LPS, whereas BPI is found in lysosomal granules of polymorphonuclear neutrophils, is bactericidal, and neutralises the toxic effects of LPS []. BPI belongs to the lipid transfer/lipopolysaccharide binding protein (LT/LBP) family, with LBP, the cholesteryl ester transfer protein (CETP) and the phospholipid transfer protein (PLTP) [].This entry represents mammalian BPI. |
