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Allele : Gt(ROSA)26Sor<tm1(Nfatc2*)Rao> gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Anjana Rao
Primary Identifier  MGI:3844634 Allele Type  Targeted
Attribute String  Conditional ready, Inserted expressed sequence, Reporter Gene  Gt(ROSA)26Sor
Transmission  Germline Strain of Origin  Not Specified
Is Recombinase  false Is Wild Type  false
molecularNote  A construct consisting of a splice acceptor site, floxed neo-stop cassette, hyperactivatable Nfatc2 gene, and an frt flanked IRES-GFP cassette was inserted into intron 1 via homologous recombination. The hyperactivatable Nfatc2 gene contains mutations in the calcineurin docking site resulting in higher affinity for ligand. The mutant protein sequence is HPVIVITGP.
  • mutations:
  • Insertion
  • synonyms:
  • R26<STOPflox-V-NFAT1>,
  • R26<STOPflox-V-NFAT1>
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1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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0 Driven By

4 Publication categories

Trail: Allele




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